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Target intelligence / Profile preview
5-hydroxytryptamine type 2C receptor (5-HT2C)
- Target
- 5-HT2C
- Molecular classification
- G protein-coupled receptor (GPCR), Class A GPCR, Receptor
01
Overview
The 5-hydroxytryptamine type 2C receptor (5-HT2C) is a serotonin receptor subtype that binds serotonin. It is a G protein-coupled receptor (GPCR) that mediates excitatory neurotransmission via coupling to Gq/G11 proteins. It is implicated in mood, appetite, anxiety, cognition, and other physiological processes. Dysfunctions are associated with neuropsychiatric conditions and metabolic syndromes.
- Other names
- 5-HT1CHTR1CSerotonin receptor 2CSerotonin (5-hydroxytryptamine) receptor 1C/2CHTR2C
02
Mechanism of action
Antagonism at 5-HT2C receptor; activation of phospholipase C signaling pathways via Gq/G11 proteins upon agonist binding.
03
Biological functions
NeurotransmissionSignal transductionDopamine modulationMood regulationAppetite controlAnxiety regulationCognitionLearningMemorySleep-wake cycle regulationThermoregulation
04
Disease associations
DepressionObsessive-compulsive disorder (OCD)Anxiety disordersSubstance use disordersObesityPrader-Willi syndrome
05
Safety considerations
Polymorphisms may contribute differentially between sexes because of their X-linked inheritance pattern.Alterations or dysfunctions involving HTR2C are implicated in various neuropsychiatric conditions and metabolic syndromes
06
Interacting drugs
Mirtazapine
1 more in the full profile.
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