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Target intelligence / Profile preview
5-Lipoxygenase-Activating Protein (FLAP)
- Target
- FLAP
- Molecular classification
- Membrane protein, Lipid mediator synthesis protein
01
Overview
5-Lipoxygenase-activating protein (FLAP) is an integral membrane protein essential for the biosynthesis of leukotrienes. It acts as a membrane anchor for the enzyme 5-lipoxygenase (ALOX5) and facilitates the conversion of arachidonic acid to leukotrienes, which are lipid mediators involved in inflammation and play significant roles in respiratory, cardiovascular, and metabolic diseases.
- Other names
- arachidonate 5-lipoxygenase activating proteinALOX5AP
02
Mechanism of action
Inhibition of leukotriene synthesis by preventing arachidonic acid presentation to 5-lipoxygenase.
03
Biological functions
Leukotriene biosynthesisArachidonic acid binding5-Lipoxygenase activation
04
Disease associations
AsthmaAllergic rhinitisCardiovascular diseasesAtherosclerosisInflammationMetabolic disorders
05
Interacting drugs
FLAP inhibitors (small-molecule inhibitors)
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