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Target intelligence / Profile preview
50S Bacterial Ribosomal Subunit (50S Ribosomal Subunit)
- Target
- 50S Ribosomal Subunit
- Molecular classification
- Ribonucleoprotein, Ribosomal Subunit
01
Overview
The 50S bacterial ribosomal subunit is an essential molecular machine responsible for catalyzing peptide bond formation during translation. Its unique structure—composed primarily of two long RNA molecules stabilized by numerous proteins—makes it an effective target for many clinically important antibiotics that disrupt bacterial growth by inhibiting protein synthesis.
- Other names
- Large Ribosomal Subunit (Prokaryotic)50S RibosomeBacterial 50S Subunit
02
Mechanism of action
Inhibition of protein synthesis via binding to the 50S ribosomal subunit and interfering with peptide bond formation, translocation, or initiation.
03
Biological functions
Peptide bond catalysisTranslationProtein synthesisG-factor bindingNascent chain protectionNascent chain folding
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistanceOff-target effects of antibioticsPotential for mitochondrial toxicity (in some cases)
06
Interacting drugs
Macrolides
5 more in the full profile.
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