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50S Ribosomal Protein L3 (L3)

Target: L3
Molecular classification: Ribosomal Protein

Overview

50S ribosomal protein L3 is a highly conserved and essential component of the large subunit (50S) of prokaryotic ribosomes. It plays a central role in ribosome assembly, structure, and function, particularly in the formation and activity of the peptidyltransferase center (PTC), which is responsible for peptide bond formation during protein synthesis. Mutations in L3 can confer resistance to antibiotics that target the PTC and affect translational fidelity.

Other names: rplC (E. coli)RPL3 (yeast)

Mechanism of action

Inhibition of peptidyltransferase activity

Biological functions

TranslationRibosome AssemblyPeptidyltransferase Activity

Disease associations

InfectionDrug Resistance

Safety considerations

Potential for off-target effects due to ribosome conservation across speciesDevelopment of drug resistance

Interacting drugs

Trichodermin

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