Target intelligence / Profile preview

50S Ribosomal Subunit (23S rRNA) (50S)

Target: 50S
Molecular classification: Ribonucleoprotein, Ribosomal RNA

Overview

The 50S ribosomal subunit is the larger component of the 70S ribosome found in prokaryotes. It consists of the 23S rRNA, 5S rRNA, and over 30 ribosomal proteins. This subunit plays a crucial role in protein synthesis, including peptidyl transfer catalysis and mRNA translation. It is also a key target for several classes of antibiotics that inhibit protein synthesis.

Other names: Large Ribosomal Subunit23S rRNA5S rRNAPeptidyl Transferase Center

Mechanism of action

Inhibition of protein synthesis by binding to the 50S ribosomal subunit, interfering with peptidyl transferase activity or tRNA binding.

Biological functions

Protein SynthesisPeptidyl Transfer CatalysismRNA TranslationtRNA BindingG-Protein Factor BindingProtein Folding Assistance

Disease associations

Infection

Safety considerations

Antibiotic resistance

Interacting drugs

Macrolides

3 more in the full profile.

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