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50S Ribosomal Subunit Protein L3
- Molecular classification
- Ribosomal Protein
01
Overview
Ribosomal protein L3 is a universally conserved and essential component of the large (50S) ribosomal subunit in prokaryotes and eukaryotes. It plays a critical role in ribosome assembly, function, and structural integrity. It is essential for forming the peptidyltransferase center (PTC), which catalyzes peptide bond formation during translation. L3 acts as a gatekeeper at the A-site, influencing aminoacyl-tRNA binding and translocation through conformational changes.
- Other names
- Ribosomal protein L3uL3 (universal nomenclature)Rpl3 (gene symbol in eukaryotes)rplC gene product (E. coli)
02
Mechanism of action
Inhibition of peptidyltransferase activity by binding to the peptidyltransferase center.
03
Biological functions
Ribosome assemblyPeptidyltransferase activitytRNA accommodationTranslational frame maintenance
04
Disease associations
Antibiotic resistanceViral replication
05
Safety considerations
Potential for off-target effects due to the highly conserved nature of ribosomal proteins.
06
Interacting drugs
Anisomycin
1 more in the full profile.
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