5S ribosomal RNA 1 (5S rRNA 1)

5S ribosomal RNA 1 is a highly conserved, approximately 120-nucleotide non-coding RNA molecule that is an integral component of the large subunit of cytoplasmic ribosomes in eukaryotes and prokaryotes, with the exception of animal and fungal mitochondrial ribosomes. It plays a critical architectural role within the central protuberance of the ribosome, physically bridging and coordinating communication among multiple functional centers necessary for protein synthesis. It interacts with ribosomal proteins and domains of large subunit rRNA to facilitate biogenesis, subunit assembly, and proper translation fidelity. While essential for ribosome structure and function, it is not itself a therapeutic drug target, nor is it a receptor, enzyme, or transporter.

Other names

5S rRNA5S ribosomal RNARNA5S1 (rare; not standard)RN5S1 (rare/variant; not standard)

Not applicable, as there are no drugs targeting 5S rRNA 1. Antibiotics affecting the ribosome may indirectly disturb 5S rRNA’s structural context, but they do not bind or modulate 5S rRNA directly.