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5S ribosomal RNA pseudogene 100 (RNA5SP100) is a human genomic sequence classified as a processed pseudogene derived from the ancestral 5S ribosomal RNA gene. 5S rRNA is an essential component of the large ribosomal subunit and plays a structural and functional role in protein synthesis, but RNA5SP100 does not produce functional ribosomal RNA nor participate in ribosome assembly[1][3][4]. Pseudogenes are defined by accumulated mutations or lack of regulatory elements, which prevent transcription of functional products; processed rRNA pseudogenes often lack introns and are dispersed throughout the genome by retrotransposition[2][4]. There is no known function or disease association for this pseudogene; it is marked only by its sequence similarity to bona fide 5S rRNA genes[2][4][6]. Note: If you require information about the *functional* 5S ribosomal RNA (5S rRNA) rather than its pseudogene, details about structural, phylogenetic, and translational roles are well characterized, but RNA5SP100 specifically is non-coding and non-functional.
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