5S ribosomal RNA pseudogene 189 (RNA5SP189)

5S ribosomal RNA pseudogene 189 (RNA5SP189) is a non-coding pseudogene that originates from the 5S rRNA gene, part of a large family of ribosomal RNA pseudogenes in the human genome. 5S rRNAs are vital structural components of ribosomes, facilitating protein synthesis in all life domains except animal and fungal mitochondria[1][3]. However, pseudogenes such as RNA5SP189 are the product of past duplication or retrotransposition events and contain mutations or truncations that disable their ability to encode functional RNA molecules[2]. As a result, RNA5SP189 is considered a non-functional remnant without reported biological function, disease association, or relevance as a druggable target. Key context: - The term "pseudogene" denotes a gene sequence that resembles a known gene (here, 5S rRNA) but is non-functional due to disabling mutations[2]. - Pseudogenes can sometimes be transcribed or exert regulatory effects (such as acting as competitive endogenous RNAs), but most are functionally inert and not involved in canonical biological processes or disease mechanisms. No such role is reported for RNA5SP189[2]. - 5S rRNA itself is crucial in ribosome structure and function, but its pseudogenes, including this one, do not have similar biological roles[1][3].

Other names

RN5S189RNA5SP189RNA, 5S ribosomal 189

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