5S ribosomal RNA pseudogene 301 (RNA5SP301)

5S ribosomal RNA pseudogene 301 (RNA5SP301) is classified as an rRNA pseudogene, meaning it is a non-functional genomic DNA sequence similar to the 5S ribosomal RNA gene but rendered inactive by disabling mutations[2][6]. Functional 5S rRNA is a short, conserved non-coding RNA molecule that is a structural component of the large ribosomal subunit and is involved in ribosome assembly and protein synthesis in all kingdoms of life (except in mitochondria of fungi and animals)[1][3][5]. Pseudogenes like RNA5SP301 are produced via gene duplication or retrotransposition, followed by the accumulation of mutations that prevent their transcription or translation. While most pseudogenes do not encode functional products, some can have regulatory effects on gene expression, and their expression patterns may correlate with disease states including cancer; however, there is no evidence that RNA5SP301 itself is involved in such mechanisms[2][4]. It is not considered a therapeutic target, has no known drug interactions, and presents no direct safety concerns. Key clarifying points: - Not a therapeutic target: RNA5SP301 has no enzymatic, receptor, transporter, or direct functional role; it is a non-functional pseudogene. - Is_incorrect: true: If queried as a conventional drug target, this is incorrect. It is not a real target but rather a genomically annotated inactive sequence[2][6]. - Not known to be clinically actionable: No drugs, mechanisms of action, or clinically established biomarkers are known for this pseudogene. - Aliases listed reflect major database nomenclature. - General note about pseudogenes: Some pseudogene expression levels may prove useful as biomarkers in cancer research and other disease states, but this is a general property of the class, not of RNA5SP301 specifically[4]. If you have a specific interest in functional 5S rRNA (rather than its pseudogenes), note that the canonical and functional target is 5S ribosomal RNA (not a pseudogene), which is an essential structural RNA in ribosomes[1][3][5].

Other names

RN5S301RNA 5S ribosomal 3015S ribosomal RNA pseudogene 301