5S ribosomal RNA pseudogene 47 (RNA5SP47)

5S ribosomal RNA pseudogene 47 is a **processed pseudogene** derived from the 5S ribosomal RNA gene[4]. Unlike the functional 5S ribosomal RNA, which is a core structural and functional component of the ribosome’s large subunit[1][3][5], a pseudogene such as RNA5SP47 does not produce a functional 5S rRNA molecule. Pseudogenes are defined as genomic DNA sequences similar to normal genes but non-functional due to mutations or lack of regulatory elements needed for transcription and translation[4]. Processed pseudogenes like RNA5SP47 typically arise by retrotransposition and lack promoters and introns and cannot encode ribosomal RNA[4]. RNA5SP47’s annotation as a “target” is incorrect: - It is not a receptor, enzyme, transporter, transcription factor, or other functional protein or RNA. - It has no pharmacological, biomarker, or safety relevance described in scientific literature. - Its only role is as a noncoding, likely non-transcribed DNA sequence in the genome[4]. Is something wrong with this target? Yes. RNA5SP47 is not a valid therapeutic or research target. It is a nonfunctional remnant of a ribosomal RNA gene (a pseudogene), rather than a molecule with known biological or clinical significance[4]. Its mention as a "target" probably reflects a misunderstanding or automatically generated annotation and should be corrected. Summary of context and core facts: - **5S ribosomal RNA** (the parent gene) is an essential structural noncoding RNA (about 120 nucleotides) component of the large ribosomal subunit in all domains of life except animal and fungal mitochondria[1][3]. The true parent gene is active, highly conserved, and central to protein synthesis. - **Pseudogenes** like RNA5SP47 often display sequence similarity to active genes but have lost their functionality and are typically not transcribed or biologically active[4]. If you are seeking therapeutic targets, 5S ribosomal RNA pseudogene 47 and similar pseudogenes do not qualify under standard classifications. If you meant the functional ribosomal RNA (5S rRNA) instead, it is a structural ribonucleic acid, not a druggable protein or receptor.

Other names

RN5S47RNA, 5S ribosomal 47RNA5SP47