5S ribosomal RNA pseudogene 66 (RNA5SP66)

5S ribosomal RNA pseudogene 66 (RNA5SP66) is a genomic DNA sequence in the human genome similar in sequence to functional 5S ribosomal RNA genes but carries sequence mutations or structural defects (such as insertions, deletions, or point mutations) that render it non-functional as an rRNA gene[4]. Pseudogenes like RNA5SP66 do not encode active RNA or protein products and are generally considered non-coding and non-functional in canonical ribosome biogenesis or protein synthesis. However, some pseudogenes can have regulatory effects on gene expression via interactions with regulatory RNAs, RNA-binding proteins, or by serving as competitive endogenous RNA decoys, though such functions are not established for this specific pseudogene[4]. There is no evidence supporting its use as a therapeutic target, biomarker, or its involvement in human disease. This molecule is not a receptor, enzyme, transporter, or transcription factor and should not be considered a drug discovery target. Key clarification: - Pseudogenes are "not active biological targets" for drugs or therapeutics and are generally marked as non-functional, non-coding DNA remnants derived from ancestral functional genes[4]. - The name sometimes leads to confusion, as "5S ribosomal RNA" is a functional and universally conserved ribosomal RNA crucial in cellular protein synthesis[1][5], but the "pseudogene" version (RNA5SP66) is not functional and not a target. Summary: RNA5SP66 is a 5S rRNA-derived pseudogene; it is non-functional, not a protein, receptor, or a conventional drug target, and its biological significance is limited to potential minor regulatory functions. If used as a molecular target in a structured dataset, it should be flagged as incorrect or not a target.

Other names

RN5S66RNA, 5S ribosomal 66RNA5SP66