5S ribosomal RNA pseudogene 75 (RNA5SP75)

5S ribosomal RNA pseudogene 75 (RNA5SP75) is a genomic DNA sequence highly homologous to functional 5S ribosomal RNA genes, but classified as a pseudogene. 5S rRNA is a component of the large ribosomal subunit essential for ribosome structure and regulation of translation[1][3][5][7]. However, pseudogenes like RNA5SP75 do not produce functional rRNA and are generally regarded as nonfunctional genomic relics produced by duplication, mutation, or retrotransposition events[8].\nIn some cases, pseudogenes are transcribed and their RNAs may play regulatory roles—such as acting as competing endogenous RNAs, antisense RNAs, or sources of small interfering RNAs—but there is no evidence that RNA5SP75 is functional in this way[2][4][6]. Most pseudogenes have no direct role in disease, drug action, or cellular signaling, and are not considered drug targets or biomarkers in clinical practice.\n\nKey clarification:\n- RNA5SP75 is specifically annotated as a pseudogene: a nonfunctional copy of a gene, not a functional RNA, protein, or therapeutic receptor/enzyme/transporter[8].\n- There is no current evidence that this specific pseudogene is druggable, involved in disease, or has a physiological function distinct from its parental 5S rRNA gene.\n- Pseudogenes *in general* can sometimes regulate their parent genes or participate in RNA silencing pathways[2][4], but such roles are not established for RNA5SP75.

Other names

RN5S75RNA5SP75RNA, 5S ribosomal pseudogene 75RNA, 5S ribosomal 75