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Target intelligence / Profile preview
5T4 Oncofetal Antigen (5T4)
- Target
- 5T4
- Molecular classification
- Type I transmembrane protein, Leucine-rich repeat (LRR) family member, Glycoprotein
01
Overview
5T4, also known as trophoblast glycoprotein (TPBG), is a 72 kDa heavily N-glycosylated transmembrane protein and a member of the leucine-rich repeat (LRR) family. It is highly expressed in placental trophoblasts and a wide range of carcinomas, but has limited expression in most normal adult tissues. 5T4 promotes EMT, potentiates chemotaxis signaling, and modulates Wnt pathways, contributing to tumor initiation, progression, invasion, metastasis, and recurrence. High levels of 5T4 are associated with poor prognosis in multiple cancers, making it a therapeutic target for cancer vaccines, antibody-drug conjugates, tumor-targeted superantigens, and CAR-T cell therapies.
- Other names
- Trophoblast glycoproteinTPBG
02
Mechanism of action
Antibody-drug conjugate targeting 5T4 induces tumor regression and reduces cancer stem cell fraction.
03
Biological functions
Epithelial-mesenchymal transition (EMT) promotionChemotaxis potentiationWnt pathway modulationTumor initiationTumor progressionInvasionMetastasisRecurrence
04
Disease associations
Cancer
05
Safety considerations
Potential for on-target, off-tumor toxicity due to expression in some normal tissues (e.g., embryonic stem cells)Immunogenicity of immunotherapeutic agents targeting 5T4
06
Interacting drugs
MEDI0641
07
Biomarkers
High 5T4 expression associated with poor prognosis in various cancersHigh 5T4 expression correlates with reduced survival rates in HNSCCHigh 5T4 expression linked to aggressive disease features (recurrence, metastasis) in ovarian cancer
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