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Target intelligence / Profile preview
5T4 Tumor-Associated Antigen (TPBG)
- Target
- TPBG
- Molecular classification
- Transmembrane glycoprotein, Oncofetal antigen
01
Overview
5T4, also known as trophoblast glycoprotein (TPBG), is a transmembrane glycoprotein highly expressed in embryonic tissues and various cancers, but minimally present in normal adult tissues. It promotes tumor progression through mechanisms like EMT induction, Wnt pathway modulation, and enhanced chemotaxis, making it an attractive target for cancer immunotherapy. Therapeutic strategies include cancer vaccines, antibody-drug conjugates, CAR-T cell therapies, and bispecific antibodies.
- Other names
- Trophoblast GlycoproteinTPBG
02
Mechanism of action
Various, including antibody-mediated cytotoxicity, immune cell activation, and direct drug delivery to tumor cells.
03
Biological functions
Epithelial-Mesenchymal Transition (EMT) inductionWnt signaling modulationCell migrationCell adhesionChemotaxis
04
Disease associations
CancerTumor progressionMetastasis
05
Safety considerations
Immune toleranceWeak endogenous immune responsesOff-target effects of immunotherapiesPotential for toxicity from antibody-drug conjugates
06
Interacting drugs
Antibody-drug conjugates (ADCs)
3 more in the full profile.
07
Biomarkers
5T4 expression levels in tumor tissueCD8+ T-cell responses against 5T4
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