6-Gingerol

6-Gingerol is the major bioactive phenolic compound found in the rhizome of ginger (Zingiber officinale). Structurally, it is characterized by a 4-hydroxy-3-methoxyphenyl group substituted at the C6 carbon by a 5-hydroxy-alkane-3-one side chain, with a chemical formula of C₁₇H₂₆O₄. It is responsible for the characteristic pungency of fresh ginger and exhibits diverse biological activities, including anti-inflammatory, antioxidant, and anti-tumor effects in preclinical models. [6]-Gingerol is not a therapeutic target itself, but rather a bioactive small molecule studied for its health benefits and mechanisms of action in cell signaling, inflammation, and metabolic regulation[1][2][3][4][5][6].

Other names

gingerol[6]-gingerol(S)-(6)-gingerol(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-onegingerolum10-gingerol

As an active component, gingerol can inhibit adipogenesis, exert anti-inflammatory and antioxidant effects, and may act on molecular pathways relevant to cancer, such as inhibition of NF-κB, COX-2, and regulation of cellular signaling[2][3].