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6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK)

Target: HPPK
Molecular classification: Enzyme, Kinase, Pyrophosphokinase

Overview

6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is an essential enzyme in the folate biosynthesis pathway of bacteria and lower eukaryotes. It catalyzes the transfer of a pyrophosphate group from ATP to 6-hydroxymethyl-7,8-dihydropterin (HMDP), producing 6-hydroxymethyl-7,8-dihydropterin-pyrophosphate (DHPPP). This reaction represents the first committed step in de novo folate synthesis. HPPK is an attractive target for antimicrobial drug development because mammals do not synthesize folates de novo.

Other names: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinasefolK

Mechanism of action

Inhibition of folate biosynthesis

Biological functions

Folate biosynthesisMetabolic pathway

Disease associations

Infection

Safety considerations

Off-target effects in beneficial bacteria

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