Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
6-Pyruvoyl Tetrahydrobiopterin Synthase (PTPS)
- Target
- PTPS
- Molecular classification
- Enzyme, Lyase
01
Overview
6-Pyruvoyl tetrahydrobiopterin synthase (PTPS) is an enzyme that catalyzes the second step in the de novo biosynthesis of tetrahydrobiopterin (BH4), a critical cofactor for several essential metabolic processes. PTPS converts 7,8-dihydroneopterin triphosphate into 6-pyruvoyltetrahydropterin with the elimination of inorganic triphosphate. Mutations in PTPS can lead to hyperphenylalaninemia due to BH4 deficiency.
02
Mechanism of action
Catalyzes the conversion of 7,8-dihydroneopterin triphosphate to 6-pyruvoyltetrahydropterin
03
Biological functions
Tetrahydrobiopterin biosynthesisAmino acid metabolismNeurotransmitter synthesis
04
Disease associations
HyperphenylalaninemiaBH4-deficient disorders
05
Safety considerations
Potential for off-target effects if directly targeted by drugsDrug interactions related to BH4 metabolism
06
Biomarkers
Dihydroneopterin triphosphate levels6-pyruvoyltetrahydropterin levels
Beyond the preview
Go deeper on 6-Pyruvoyl Tetrahydrobiopterin Synthase (PTPS).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 6-Pyruvoyl Tetrahydrobiopterin Synthase (PTPS).