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60S ribosomal protein L10-like (RPL10L)
- Target
- RPL10L
- Molecular classification
- Other (ribosomal protein family; not currently known to be a functional ribosomal component in humans)
01
Overview
60S ribosomal protein L10-like (RPL10L) is a protein encoded by the *RPL10L* gene in humans and is located on chromosome 14[3]. RPL10L shows high sequence similarity to ribosomal protein L10 (RPL10), a well-characterized component of the large (60S) ribosomal subunit[1]. The *RPL10L* gene is intronless and may have arisen through retro-transposition as a potential compensatory gene during spermatogenesis, with expression reported as testis-specific in studies of RPL10L[1][3]. Unlike RPL10, which is critical for ribosome biogenesis and has clear links to both normal physiology and disease (including cancer and ribosomopathies)[1][5], it is currently unknown whether RPL10L serves as a functional ribosomal protein in humans or if it possesses any independent biological activity; there are no established disease associations, molecular interactions, or roles as a therapeutic target[3].
- Other names
- RPL10Lribosomal protein L10-like
02
Mechanism of action
Not established
03
Biological functions
Unknown/unclear; shares sequence similarity with ribosomal protein L10, but its specific function is not determinedPutative involvement in ribosomal biology due to homology
04
Disease associations
None clearly established for RPL10L itselfNo evidence for involvement in cancer, inflammation, or other diseases (as opposed to RPL10, which is implicated in several)
05
Safety considerations
None known
06
Interacting drugs
None known
07
Biomarkers
None known
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