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60S ribosomal protein L13 (RPL13)
- Target
- RPL13
- Molecular classification
- Ribosomal protein, Structural constituent of ribosome, Other
01
Overview
60S ribosomal protein L13 (RPL13) is a highly conserved protein that is a component of the large (60S) ribosomal subunit, essential for the synthesis of cellular proteins[1][2][3]. RPL13 is part of the L13E family of ribosomal proteins and is located in the cytoplasm. Besides its canonical role in protein synthesis, RPL13 has emerging extraribosomal functions: it regulates cell proliferation, participates in cellular stress responses, and plays critical roles in bone and heart development[3]. It is upregulated in various cancers and is associated with disease progression and chemoresistance. RPL13 also participates in the innate immune response and antiviral defense mechanisms, modulating NF-κB and interferon signaling pathways[4]. Mutations in RPL13 cause certain rare congenital skeletal disorders. There are no approved drugs that directly target RPL13, and it is not currently considered a direct therapeutic target.
- Other names
- Large ribosomal subunit protein eL13BBC1OK/SW-cl.46D16S444EL13eL13Breast basic conserved protein 1breast basic conserved 1SEMDIST60S ribosomal protein L13
02
Biological functions
Protein synthesisStructural component of ribosomeCell proliferationBone developmentInnate immune responseRegulation of cell cycle
03
Disease associations
CancerCongenital syndromes (e.g., spondyloepimetaphyseal dysplasia)Infection (antiviral response)Other (skeletal and cardiac development disorders)
04
Safety considerations
Potential impact on cell proliferation and chemoresistance in cancer if therapeutically targetedDisruption may contribute to developmental defects (bone, cardiac)
05
Biomarkers
Elevated RPL13 expression as biomarker in some cancers, e.g. gastrointestinal cancersMarker for certain bone development disorders
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