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Target intelligence / Profile preview
60S ribosomal protein L14 (RPL14)
- Target
- RPL14
- Molecular classification
- Ribosomal protein, Structural constituent of ribosome, Other
01
Overview
60S ribosomal protein L14 (RPL14) is a cytoplasmic component of the large 60S subunit of the ribosome in humans, belonging to the L14E family of ribosomal proteins. It plays an essential structural role in ribosome assembly and function, facilitating the synthesis of proteins. The protein contains a basic region-leucine zipper (bZIP)-like domain, and the gene includes a highly polymorphic trinucleotide (GCT) repeat. It does not act as a classic therapeutic target such as an enzyme, receptor, or transporter, but rather as an essential housekeeping protein involved in translation[1][4][5].
- Other names
- Large ribosomal subunit protein eL14L14hRL14RL14CTG-B33eL1460S ribosomal protein L14CAG-ISL 7CAG-ISL-7
02
Biological functions
Protein synthesisStructural constituent of ribosomerRNA processingRibosomal large subunit biogenesis
03
Disease associations
Cancer (based on general roles of ribosomal proteins in cancer and cellular proliferation, but no specific frequent association recorded for RPL14 itself)Other
04
Safety considerations
Disruption or mutation can potentially impair protein synthesis and cell viability, but no specific therapeutic safety concerns identified
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