60S ribosomal protein L15 (RPL15)

60S ribosomal protein L15 is a highly conserved structural protein that forms part of the large subunit (60S) of eukaryotic ribosomes, essential for cellular protein synthesis[3][5]. RPL15 participates in ribosome assembly, rRNA maturation, and nucleolar function[1][2]. Its gene (RPL15) encodes a cytoplasmic protein, which is upregulated in several cancers (notably colon, esophageal, and gastric) and is deleted in some patients with Diamond-Blackfan anemia[1][5]. Elevated RPL15 expression in cancers is linked with increased cell proliferation and poor prognosis, while experimental depletion induces cell cycle arrest or apoptosis, supporting its consideration as a novel cancer biomarker and therapeutic target[1][3][5].

Other names

Ribosomal protein L15RPL15RL1560S ribosomal protein L15ribosome protein L15

Induction of ribosomal stress: Small molecule depletion or knockdown approaches can cause disruption of ribosome assembly leading to cell cycle arrest or apoptosis. Future approaches may aim to selectively target cancers overexpressing RPL15, leveraging its role in nucleolar structure and ribosome biogenesis.