Target intelligence / Profile preview

60S ribosomal protein L18 (RPL18)

Target
RPL18
Molecular classification
Other (Ribosomal protein)
01

Overview

60S ribosomal protein L18 (RPL18) is a structural protein component of the large (60S) ribosomal subunit in eukaryotic cells, crucial for protein synthesis as part of the ribosome complex. It is encoded by the RPL18 gene on chromosome 19, belongs to the L18E family of ribosomal proteins, and is found in the cytoplasm. Like other ribosomal proteins, there are multiple processed pseudogenes of RPL18 scattered throughout the genome. Mutations in RPL18 have been associated with Diamond-Blackfan anemia, a rare congenital red cell aplasia[1][2][3][4][5][6].

Other names
Ribosomal protein L18Large ribosomal subunit protein eL18L18eL18DBA1860S ribosomal protein L18
02

Biological functions

Protein synthesisPeptide chain elongation
03

Disease associations

Diamond-Blackfan anemiaCancer (general ribosomal protein implication, not specific)Other

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