60S ribosomal protein L21 (RPL21)

60S ribosomal protein L21 is a structural component of the large (60S) subunit of cytoplasmic ribosomes, organelles responsible for catalyzing protein synthesis in cells[2][3][1]. RPL21 belongs to the L21E family of ribosomal proteins and primarily functions in translation as part of the ribosome. Beyond its canonical role, RPL21 (also known as eL21) demonstrates extra-ribosomal functions; for example, it interacts with the lysine methyltransferase SMYD2, influencing cell proliferation and potentially contributing to oncogenic processes when dysregulated[1][6]. Mutations in RPL21 are causative for hereditary hypotrichosis simplex, a non-syndromic form of hair loss[1][2][3][4]. There are currently no drugs known to directly target RPL21, and its use as a drug target is not established; rather, its significance is primarily in fundamental biology and as a disease gene in specific hereditary and potentially oncogenic contexts.

Other names

ribosomal protein L21eL21L21HYPT12FLJ27458MGC71252MGC104274MGC104275DKFZp686C0610160S ribosomal protein L21