60S ribosomal protein L35a (RPL35A)

60S ribosomal protein L35a (RPL35A) is a protein encoded by the RPL35A gene, which is a structural component of the large 60S subunit of cytoplasmic ribosomes[1][4][7]. Ribosomes are essential organelles that catalyze the translation of mRNA into proteins and are made up of two subunits (40S and 60S), together comprised of ribosomal RNAs and numerous ribosomal proteins including L35a[1][4][6][7]. L35a is part of the L35AE family, is highly conserved across eukaryotes, and in rats, it is located at or near the P (peptidyl) and/or A (aminoacyl) sites of the ribosome, binding both initiator and elongator tRNAs[4]. Mutations in RPL35A cause Diamond-Blackfan anemia type 5, a rare disorder of the bone marrow manifested by red cell aplasia (anemia) and congenital abnormalities due to the effects on ribosome biogenesis—specifically, defects in rRNA processing and maturation, leading to increased apoptosis of blood-forming cells[1][2][6][7]. Currently, there are no drugs that directly target RPL35A, and it is not considered a pharmacological target, but RPL35A mutation serves as a diagnostic biomarker for Diamond-Blackfan anemia[1][6].

Other names

60S ribosomal protein L35aRPL35AeL33L35AGIG33DBA5cell growth-inhibiting gene 33 proteinRL35A_HUMAN