60S ribosomal protein L37 (RPL37)

60S ribosomal protein L37 is a structural component of the large (60S) subunit of cytoplasmic ribosomes, which are the cellular complexes responsible for catalyzing protein synthesis in eukaryotes[1][2][3]. It is encoded by the RPL37 gene and contains a characteristic C2C2-type zinc finger-like motif[1][4]. RPL37's primary role is as a structural constituent of the ribosome, but like some ribosomal proteins, it may also interact with cellular regulatory proteins such as MDM2/MDMX, thereby potentially linking ribosome biogenesis to cell cycle regulation and tumor suppression pathways[2][7]. Diseases associated with defects in RPL37 include Diamond-Blackfan anemia and certain types of cataract[3]. Several antibiotics—such as puromycin and anisomycin—can interact with ribosomal proteins, inhibiting translation and thus protein synthesis[2]. There are no established therapeutic drugs directly and selectively targeting RPL37 given its ubiquitous and essential role in normal cells.

Other names

Large ribosomal subunit protein eL3760S ribosomal protein L37G1.16(gene: RPL37)

Inhibition of protein synthesis (by interfering with ribosome function for certain antibiotics)[2]