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Target intelligence / Profile preview
60S ribosomal protein L37a (RPL37A)
- Target
- RPL37A
- Molecular classification
- Ribosomal protein, Structural protein of the ribosome, L37AE family of ribosomal proteins
01
Overview
60S ribosomal protein L37a is a component of the large 60S ribosomal subunit in human cells, essential for ribosome structure and function. It belongs to the L37AE family and contains a C4-type zinc finger-like domain, localizing in the cytoplasm as part of the ribosome. The protein is involved in translation and has processed pseudogenes throughout the genome as is typical for ribosomal proteins. Mutation or altered expression may be associated with diseases such as Diamond-Blackfan anemia and certain cancers. However, it is primarily classified as a housekeeping, structural protein and is not a conventional therapeutic target.
- Other names
- Ribosomal protein L37aL37Alarge ribosomal subunit protein eL43eL43
02
Mechanism of action
Not applicable, since it is not known to be a drug target
03
Biological functions
Structural constituent of ribosomeCatalysis of protein synthesis (translation)RNA bindingMetal ion binding
04
Disease associations
Diamond-Blackfan anemiaOvarian mucinous adenocarcinomaOther roles in development and disease based on gene expression associations, but limitations on causality
05
Safety considerations
No direct safety concerns or therapeutic challenges specific to RPL37A; ribosomal proteins are essential for cell viability, and nonspecific inhibition could cause cytotoxicity
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