Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
60S ribosomal protein L38 (RPL38)
- Target
- RPL38
- Molecular classification
- Ribosomal protein, Structural constituent of ribosome, Other
01
Overview
60S ribosomal protein L38 (RPL38) is a structural component of the large (60S) subunit of the eukaryotic ribosome, encoded by the RPL38 gene on chromosome 17. It is part of the L38E family, located in the cytoplasm, and participates in catalyzing cellular protein synthesis during translation. It does not have a direct enzymatic or receptor-related role and is not targeted by current therapeutics. Mutations in animal models cause anemia, skeletal malformations, and hearing loss but in humans, no pathogenic mutations have been definitively linked to disease.
- Other names
- Large ribosomal subunit protein eL38RPL38L38eL3860S ribosomal protein L38ribosomal protein L38TsTSSLOC6882480610025G13RIKRBT
02
Mechanism of action
Not applicable; no drugs are known to act specifically on this protein.
03
Biological functions
Protein synthesis (translation)Structural component of ribosomeRNA bindingRegulation of gene expression (minor, through translational specificity in some species)
04
Disease associations
Diamond-Blackfan anemia (other ribosomal proteins; no human disease yet linked directly to RPL38 mutations but animal models demonstrate developmental defects)Klippel-Feil syndrome 2 (association, if any, is minor)Tympanosclerosis (association, if any, is minor)Skeletal malformations and anemia in mouse modelsHearing loss (mouse)
05
Safety considerations
Not applicable for drug targeting.Mutations in ribosomal proteins generally may contribute to developmental disorders and anemia
06
Interacting drugs
None known; ribosomal proteins are not typical drug targets in humans.
07
Biomarkers
None established for patient selection or efficacy monitoring.
Beyond the preview
Go deeper on 60S ribosomal protein L38 (RPL38).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 60S ribosomal protein L38 (RPL38).