60S ribosomal protein L6 pseudogene

60S ribosomal protein L6 pseudogene is a non-functional, processed pseudogene copy of the RPL6 gene, which encodes a protein component of the large (60S) ribosomal subunit. Ribosomal protein pseudogenes, such as those derived from RPL6, commonly arise through retrotransposition events and are dispersed throughout the genome. They typically do not encode functional proteins and are distinguished from the intact RPL6 gene, which is crucial for protein synthesis in the cytoplasm. Most ribosomal pseudogenes lack biological activity and are not considered as therapeutic targets. Key details: - This entry does not encode a protein and does not participate in protein synthesis or other known cellular functions. - There are many ribosomal protein pseudogenes similar to ENSG00000187472 throughout the human genome as a result of evolutionary retrotransposition events. - The functional RPL6 gene (not this pseudogene) is associated with ribosome function, transcriptional regulation, and some diseases such as Noonan syndrome and T-cell acute lymphoblastic leukemia, but pseudogenes do not share these functional associations. - Common confusion exists between true ribosomal protein genes and their respective pseudogenes in genomic databases; careful annotation is required. Critical notes: - ENSG00000187472 is explicitly listed as a pseudogene in comprehensive gene databases and does not produce a functional protein. - It should not be considered a druggable or functional therapeutic target. - For scientific or therapeutic interest, the focus should be on the functional gene, 60S ribosomal protein L6 (RPL6). If structured data is required for therapeutic pipelines, this entry should be marked as incorrect for targeting purposes and excluded from target lists.

Other names

Ribosomal Protein L6 PseudogeneRPL6PRPL6P27