60S ribosomal protein L7a (RPL7A)

60S ribosomal protein L7a (RPL7A) is a key structural component of the large (60S) ribosomal subunit, belonging to the L7AE family of ribosomal proteins. It functions in the cytoplasm as part of the ribosome, catalyzing protein synthesis (translation). RPL7A contains two RNA-binding domains and participates directly in the assembly and functioning of ribonucleoprotein complexes. Beyond its structural roles, RPL7A can interact with a subset of nuclear hormone receptors, such as the thyroid hormone receptor, modulating their ability to activate gene transcription by blocking receptor-DNA binding. Expression of RPL7A can be altered in disease contexts—including upregulation and downregulation in breast cancer and osteosarcoma, respectively—suggesting roles in tumor progression and diagnosis. Gene rearrangement involving RPL7A and the trk proto-oncogene can result in oncogenic proteins. RPL7A is not a typical drug target, but it is of pathological and potential biomarker relevance in several diseases, notably certain cancers and genetic disorders.

Other names

L7aSURF3TRUPribosomal protein L7aLarge ribosomal subunit protein eL8PLA-X polypeptideSurfeit locus protein 3surfeit 3thyroid hormone receptor uncoupling proteineL8