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Target intelligence / Profile preview
70 kDa Ribosomal Protein S6 Kinase (p70S6K)
- Target
- p70S6K
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
The 70 kDa ribosomal protein S6 kinase (p70S6K or S6K1) is a serine/threonine protein kinase that plays a central role in cell growth, proliferation, and metabolism. It is activated primarily via the PI3K/mTOR pathway and phosphorylates the ribosomal protein S6, enhancing translation of mRNAs involved in protein synthesis machinery. Dysregulation of p70S6K is implicated in cancer, obesity, diabetes, and aging, making it a therapeutic target and a biomarker for mTOR inhibitor response.
- Other names
- S6K1Ribosomal protein S6 kinase beta-1p70S6 kinasep70-S6 Kinase
02
Mechanism of action
Phosphorylation of ribosomal protein S6 and eIF4B, promoting translation of mRNAs with a 5'TOP motif; activation downstream of the PI3K/mTOR pathway.
03
Biological functions
Cell cycleCell growthCell survivalGlucose homeostasismRNA processingTranslation initiationProtein synthesis
04
Disease associations
CancerObesityDiabetesAging
05
Safety considerations
Narrow therapeutic index of upstream inhibitors like rapamycin.
06
Interacting drugs
Rapamycin
2 more in the full profile.
07
Biomarkers
Plasma levels of p70S6 kinase (for monitoring mTOR inhibitor response)
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