Target intelligence / Profile preview

8-((2-hydroxybenzoyl)amino)octanoate (SHAO)

Target: SHAO
Molecular classification: Amphiphilic molecule, Excipient, Drug delivery enhancer

Overview

SHAO (8-((2-hydroxybenzoyl)amino)octanoate), also known as salcaprozic acid or salcaprozate sodium (when in salt form), is an amphiphilic molecule used as a drug delivery enhancer. It improves the solubility and membrane permeability of co-administered drugs, facilitating their absorption and distribution. It is notably used in oral formulations to enhance the bioavailability of poorly absorbed macromolecules like peptides and proteins, and in intratumoral cancer therapies to improve local drug distribution while reducing systemic toxicity.

Other names: Salcaprozic acid8-(2-Hydroxybenzamido)octanoic acidSodium N-(8-(2-hydroxybenzoyl)amino)caprylateSalcaprozate sodiumSNACSHOA

Mechanism of action

SHAO enhances both aqueous and lipid solubility of co-administered drugs, facilitating passive transmembrane cell penetration. It forms supramolecular complexes with active pharmaceutical ingredients, improving delivery into target cells/tissues.

Biological functions

Enhances drug solubilityEnhances membrane permeabilityPromotes drug absorptionIncreases drug dispersion in tissues

Disease associations

Cancer (as part of drug delivery systems)Diabetes (potential for oral insulin delivery)

Safety considerations

Potential for off-target effects due to enhanced drug permeability.Safety profile needs careful evaluation when co-administered with cytotoxic agents.

Interacting drugs

Cisplatin

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