85 kDa calcium-independent phospholipase A2 (PLA2G6) (iPLA2-beta)

The 85 kDa calcium-independent phospholipase A2 (iPLA2-beta), encoded by the PLA2G6 gene, is a key enzyme involved in phospholipid remodeling and the release of arachidonic acid (UniProt: O60733). It operates independently of calcium, distinguishing it from other PLA2 family members, and is localized primarily in the cytosol and mitochondria (PubMed: 25624351). This enzyme plays a vital role in maintaining cell membrane integrity, regulating apoptosis, and facilitating insulin secretion from pancreatic beta cells (NCBI Gene: 10178). Mutations in PLA2G6 are strongly associated with neurodegenerative conditions, including infantile neuroaxonal dystrophy (INAD) and Parkinson's disease, highlighting its importance in neuronal health (PubMed: 30143541). While it is a target for anti-inflammatory and anti-cancer drug development, its broad physiological roles present challenges for achieving selectivity and avoiding systemic toxicity.

Other names

Group VIA phospholipase A2PLA2G6iPLA2-VICalcium-independent phospholipase A2-betaPNPLA9

Inhibition of the enzyme's catalytic activity to prevent the hydrolysis of the sn-2 ester bond of phospholipids, thereby reducing the release of free fatty acids and lysophospholipids (PubMed: 25624351).