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Target intelligence / Profile preview
A Disintegrin And Metalloprotease 10 (ADAM10)
- Target
- ADAM10
- Molecular classification
- Metalloprotease, Transmembrane protein, ADAM family
01
Overview
ADAM10 is a versatile membrane-bound metalloproteinase central to regulating intercellular communication through controlled proteolysis at the cell surface. Its structural complexity allows tight regulation via autoinhibition/autoregulation mechanisms involving non-catalytic domains. Given its broad substrate range—including key players in cancer biology and neurodegenerative diseases—it remains an important therapeutic target under active research for selective modulation strategies.
02
Mechanism of action
Small molecule inhibitors/activators or antibodies targeting regulatory domains to modulate its sheddase function selectively.
03
Biological functions
Ectodomain sheddingCell signaling regulationProteolysisDendritic spine formation/maturation/stabilizationGlutamatergic synapse organization
04
Disease associations
Cancer progression/metastasisAlzheimer’s disease/neurodegenerationAutoimmune disordersInflammation
05
Safety considerations
Off-target effects due to broad substrate range
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