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A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)
- Target
- ADAMTS5
- Molecular classification
- Enzyme, Metalloproteinase, Proteoglycanase
01
Overview
A secreted, multidomain zinc-dependent protease that functions primarily as an aggrecanase, cleaving aggrecan and other ECM components. It plays a critical role in cartilage structure and function and is implicated in osteoarthritis, rheumatoid arthritis, and cancer biology. Its activity is regulated by TIMP3 and other factors.
- Other names
- aggrecanase-2ADAM-TS 11ADAM-TS 5ADAM-TS5ADAMTS-11ADAMTS-5ADAMTS11ADMP-2
02
Mechanism of action
Inhibition of metalloproteinase activity
03
Biological functions
Connective tissue organization and developmentCartilage homeostasisExtracellular matrix remodelingInflammation regulationCell migration regulationAnti-angiogenesis
04
Disease associations
OsteoarthritisRheumatoid arthritisCancer
05
Safety considerations
Excessive inhibition may disrupt normal ECM turnoverPotential for off-target effects due to structural similarity with other ADAMTS family members
06
Interacting drugs
TIMP3
1 more in the full profile.
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