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Target intelligence / Profile preview
A-kinase anchor inhibitor 1 (AKAIN1)
- Target
- AKAIN1
- Molecular classification
- Binding protein, Protein kinase A-binding protein, Disruptor of PKA–AKAP interaction, Other
01
Overview
A-kinase anchor inhibitor 1 (AKAIN1) is a protein-coding gene and short protein, enriched in neural tissue, that enables protein kinase A (PKA) binding activity and is involved in protein localization within the cytosol. Unlike classic A-kinase anchoring proteins (AKAPs) which tether PKA to defined subcellular locations, AKAIN1 disrupts PKA–AKAP interactions, thereby modulating the localization and signaling of PKA. It preferentially binds to PKA type II regulatory subunits and is predicted to function as an endogenous disruptor of PKA–AKAP anchoring. While not itself a direct drug target, AKAIN1 may be relevant to signaling pathways involved in neural plasticity and mood disorders through its regulatory influence on PKA localization and activity.
- Other names
- C18orf42A-kinase anchor protein inhibitor 1A kinase (PRKA) anchor inhibitor 1A-kinase anchor protein C18orf42
02
Mechanism of action
Not applicable (as AKAIN1 is not a drug target; it modulates PKA signaling by inhibiting anchoring, which may indirectly impact drug responses involving PKA signaling)
03
Biological functions
Protein kinase A bindingModulation of intracellular PKA localizationNeural tissue enrichmentRegulation of signal transduction via PKA
04
Disease associations
Chromosome 18p deletion syndrome (listed in gene-disease associations)Potential genetic modifier for antidepressant response (based on its involvement in neural PKA signaling, but not established as a causal disease gene)Other
05
Biomarkers
Genetic variation in AKAIN1 may be a potential biomarker for antidepressant response
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