A-kinase anchoring protein 19 (AKAP19)

A-kinase anchoring proteins (AKAPs), including the entity sometimes referred to as *A-kinase anchoring protein 19* or *small membrane AKAP (smAKAP)*, comprise a diverse family of scaffold proteins defined primarily by their affinity for the regulatory subunit of protein kinase A (PKA)[1][2][3][4]. AKAPs compartmentalize PKA within the cell, targeting the kinase to specific subcellular domains to orchestrate precise and localized signaling events. This dynamic localization allows PKA and other associated enzymes (e.g., phosphodiesterases and phosphatases) to act efficiently and specifically in response to cAMP and other stimuli, thereby regulating processes including gene transcription, ion channel activity, and cell morphology[1][2][3][4]. While the broader AKAP family (including AKAP18, AKAP79, and AKAP150) has substantial functional and disease relevance, information regarding AKAP19/smAKAP is sparse and inconsistent in recognized scientific databases. Most features and biological roles attributed here are based on the general properties of AKAP family members, as specific roles for AKAP19 remain less well defined in the literature. If further structural or functional information about "AKAP19" becomes available in reference databases, disease contexts, or high-profile studies, these core entries should be revised accordingly. Current ambiguity in the name and lack of druggability or biomarker status indicate this is not a canonical or well-validated therapeutic target[1][2][3][4].

Other names

Small membrane A-kinase anchor proteinsmAKAPC2orf88Small membrane AKAPSmall A-kinase anchoring proteinMGC13057

Not applicable for direct drug interaction; generally, AKAPs control the localization and assembly of PKA and other proteins to spatially direct phosphorylation responses in cells[2][3][4].