A-kinase anchoring protein 5 (AKAP5)

A-kinase anchoring protein 5 (AKAP5) is a multivalent scaffold protein encoded by the AKAP5 gene, primarily recognized for anchoring cAMP-dependent protein kinase A (PKA) to specific subcellular locations such as postsynaptic densities in neurons and specialized microdomains in cardiomyocytes[1][2][3][4]. AKAP5 forms the core of macromolecular signalosomes, binding PKA, protein kinase C, calcineurin, and other signaling partners to precisely coordinate signaling events governing calcium cycling, synaptic plasticity, immune responses, and cardiac contractility[1][2][3][4][6]. Dysregulation or loss of AKAP5 affects neuronal signaling, T-lymphocyte activation, and is strongly implicated in cardiac pathology (hypertrophy, heart failure, arrhythmias) due to its essential role in maintaining calcium homeostasis and integrating β-adrenergic signaling pathways[2][4]. Although no drugs directly target AKAP5, its scaffolding function is central to diverse physiological processes and emerging research suggests a potential therapeutic interest in modulating AKAP5-protein complexes for cardiovascular disease[2][3].

Other names

AKAP79AKAP75AKAPs-5Protein kinase A anchoring protein 5Kinase anchor protein 5

Modulation of β-adrenergic receptor (β-AR) signaling in cardiomyocytes; Regulation of PKA-mediated phosphorylation of key calcium-handling proteins (e.g., phospholamban, ryanodine receptor 2); Scaffolding of protein complexes to orchestrate local cAMP/PKA/PKC/calcineurin signaling