A-kinase anchoring protein 6 (AKAP6)

A-kinase anchoring protein 6 (AKAP6) is a large, scaffolding protein that anchors type II regulatory subunits of protein kinase A (PKA) to specific subcellular compartments such as the nuclear membrane and sarcoplasmic reticulum[1][2][5]. AKAP6 thereby enables the spatial and temporal compartmentalization of cAMP/PKA signaling, optimizing signal transduction by assembling multiprotein complexes and directing signaling enzymes toward specific substrates[1][2][3][5]. Highly expressed in cardiac and skeletal muscle as well as the brain, AKAP6 plays critical roles in cardiac hypertrophy, nuclear envelope microtubule-organizing center function, skeletal muscle differentiation, and neuroprotection, especially in the survival of retinal ganglion cells after injury[3][4][2]. Disease associations include cardiac arrhythmias (Long QT syndrome), and it is being investigated for its role in neurodegenerative and cardiovascular conditions[1][4]. Drugs specifically targeting AKAP6 have not been reported; therapeutic strategies would likely modulate its scaffolding functions in PKA signaling complexes[1][2][4].

Other names

mAKAPAKAP100PRKA6ADAP100ADAP6KIAA0311Protein kinase A-anchoring protein 6A-kinase anchor protein 100 kDa

Drug mechanisms not well documented for this scaffold protein; any action would likely involve modulation of PKA signaling or targeting of anchoring interactions.