A-kinase anchoring protein 7 (AKAP7)

A-kinase anchoring protein 7 (AKAP7) is a member of the AKAP family of scaffolding proteins, characterized by their ability to bind the regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific intracellular compartments[1][2][3]. AKAP7 encodes several isoforms (including alpha, beta, and gamma) that localize PKA to distinct subcellular locations, thereby spatially organizing cAMP signaling. The major neuronal isoform (AKAP7α) anchors PKA at presynaptic sites in the hippocampus and other brain regions, where it is essential for anchoring PKA-RIIβ, regulating synaptic plasticity, and affecting learning and memory. The gamma isoform includes a phosphodiesterase-like domain, but its biochemical function is incompletely understood[4]. AKAP7 has emerging roles as a biomarker in certain diseases and is regarded as a key regulator of compartmentalized signal transduction[1][2][3][4].

Other names

A-kinase anchor protein 7 isoform gammaAKAP18AKAP-7 isoform gammaPRKA7 isoform gammaA-kinase anchor protein 7 isoforms alpha and betaAKAP15AKAP-7 isoforms alpha and betaPRKA7 isoforms alpha/betaA-kinase anchor protein 18 kDaProtein kinase A-anchoring protein 7 isoforms alpha/betaProtein kinase A-anchoring protein 7 isoform gammaA kinase (PRKA) anchor protein 7A-kinase anchor protein 9 kDaAKAP 18

(For AKAP inhibitors: disruption of PKA anchoring to AKAP7, thereby altering subcellular localization of PKA and its downstream signaling)