A-kinase anchoring protein 8 pseudogene 1 (AKAP8P1)

A-kinase anchoring protein 8 pseudogene 1 (AKAP8P1) is a processed pseudogene located on human chromosome 9p23[3], derived from the protein-coding gene AKAP8[1][9]. As a pseudogene, AKAP8P1 does not produce a functional protein and is **not considered a therapeutic target** such as a receptor, enzyme, or transporter. While pseudogenes have historically been thought of as nonfunctional, recent research suggests some pseudogenes may participate in regulation of gene expression via noncoding RNA mechanisms, including acting as microRNA decoys or generating siRNAs, but **no specific biological activities, disease associations, or drug interactions have been reported for AKAP8P1 itself**[1][3][5][7][9]. The parent gene, AKAP8, encodes a nuclear scaffolding protein involved in PKA signaling and chromatin regulation[4][2][10], but these functions do not apply to AKAP8P1. Thus, AKAP8P1 should not be considered a therapeutic target, and its primary significance is as a **noncoding genomic element**. **Key points:** - **AKAP8P1 is a pseudogene, not a protein-coding gene or receptor[1][3][7][9].** - **AKAP8P1 is not a therapeutic target; it does not interact with drugs or have a defined mechanism of action.** - **Listing AKAP8P1 among therapeutic targets is incorrect**; registry or assays should be revised to exclude it for such uses.

Other names

A kinase (PRKA) anchor protein 8 pseudogene 1AKAP8P1A kinase anchoring protein 8 pseudogene 1