A-kinase anchoring protein 9 (AKAP9)

A-kinase anchoring protein 9 (AKAP9) is a large scaffolding protein that localizes to the centrosome and Golgi apparatus, where it anchors protein kinase A (PKA) and assembles multiple signaling molecules involved in diverse cell signaling pathways. AKAP9 facilitates the spatial and temporal organization of signaling enzymes, especially those involved in microtubule nucleation and cell cycle progression. By recruiting kinases (such as PKA, Cdk2, protein kinase N) and phosphatases, it orchestrates events crucial for cellular organization, mitosis, DNA synthesis, and cytoskeletal maintenance. Pathogenic mutations in the AKAP9 gene are implicated in diseases such as Long QT syndrome type 11 and have also been linked to some cancers. While there are currently no approved therapeutics directly targeting AKAP9, disruption of its interactions is being explored as a strategy to modulate signaling in diseases associated with aberrant cell cycle control and cytoskeletal organization.

Other names

AKAP350AKAP450CG-NAPPRKA9KIAA0803HYPERIONPPP1R45YotiaoLQT11MU-RMS-40.16AProtein hyperionProtein kinase A anchoring protein 9Protein yotiaoCentrosome- and Golgi-localized PKN-associated proteinA-kinase anchor protein, 350 kDaA-kinase anchor protein, 450 kDaAKAP9-BRAF fusion proteinA kinase (PRKA) anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9

Experimental agents may disrupt protein-protein interactions between PKA and AKAP9, altering downstream signaling associated with microtubule dynamics and cell cycle progression.