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Target intelligence / Profile preview
A Proliferation-Inducing Ligand (APRIL)
- Target
- APRIL
- Molecular classification
- Tumor Necrosis Factor (TNF) Ligand Superfamily
01
Overview
A Proliferation-Inducing Ligand (APRIL), also known as TNFSF13 or CD256, is a member of the tumor necrosis factor (TNF) ligand superfamily. It promotes B cell survival, immunoglobulin class switching, and has been implicated in autoimmune diseases and cancer. APRIL interacts primarily with BCMA, TACI, and Heparan Sulfate Proteoglycans (HSPGs).
- Other names
- TNFSF13CD256TALL2TRDL1ZTNF2UNQ383/PRO715TNLG7B
02
Mechanism of action
Inhibition of APRIL reduces proteinuria and slows kidney disease progression in IgA nephropathy.
03
Biological functions
Immune responseB cell activationB cell proliferationPlasma cell survivalImmunoglobulin class switchingAntibody productionApoptosis (in vitro, potential)
04
Disease associations
AutoimmunityIgA NephropathyCancerCoronary Artery Disease
05
Biomarkers
Elevated serum levels in autoimmune diseasesElevated serum levels in cancerElevated serum concentrations in coronary artery disease
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