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Target intelligence / Profile preview
A-type Potassium Channel (Kv4)
- Target
- Kv4
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel
01
Overview
A-type potassium channels are a subclass of voltage-gated potassium channels characterized by rapid activation and inactivation kinetics. They play a crucial role in regulating neuronal excitability, action potential duration, and interspike interval. These channels are tetrameric proteins that form a central pore for potassium ion flow. Dysfunction of A-type potassium channels is implicated in various pathological conditions, including cardiac arrhythmias and neurological disorders. Pharmacological modulation of these channels may have therapeutic potential for conditions related to neuronal hyperexcitability, pain, ischemia, and migraine.
- Other names
- Transient outward potassium current channelFast-inactivating potassium channel
02
Mechanism of action
Channel blockade, modulation of channel kinetics (activation, inactivation)
03
Biological functions
Regulation of neuronal excitabilityAction potential repolarizationSetting interspike intervalRegulation of membrane potentialNeuronal signalingFacilitated diffusion of potassium ions
04
Disease associations
Cardiac arrhythmiasNeurological disordersVascular disordersEpilepsyAtaxia
05
Safety considerations
Potential for off-target effects on other potassium channelsRisk of cardiac arrhythmiasPotential for neurotoxicity at high doses
06
Interacting drugs
Dendrotoxin
3 more in the full profile.
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