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Target intelligence / Profile preview
A3 Adenosine Receptor (A3AR)
- Target
- A3AR
- Molecular classification
- G protein-coupled receptor (GPCR), Receptor
01
Overview
The A3 adenosine receptor (A3AR), also known as ADORA3, is a G protein-coupled receptor (GPCR) that plays diverse roles in physiological and pathological processes. It is implicated as a therapeutic target for multiple conditions including rheumatoid arthritis, myocardial ischemia, bronchial asthma, and inflammatory diseases. A3AR primarily couples to Gi/Gq proteins, inhibiting adenylyl cyclase activity. Intense activation can induce cell death while low-level activation may be cytoprotective.
- Other names
- ADORA3
02
Mechanism of action
Agonists activate A3AR, leading to Gi/Gq protein coupling and inhibition of adenylyl cyclase. Antagonists block A3AR activation.
03
Biological functions
Signal transductionCardioprotectionImmune modulationNeuroprotectionNeurodegenerationRegulation of cell proliferationApoptosis
04
Disease associations
Rheumatoid arthritisMyocardial ischemiaCerebral ischemiaBronchial asthmaInflammatory diseases
05
Interacting drugs
CF101 (IB-MECA/Piclidenoson)
7 more in the full profile.
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