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Target intelligence / Profile preview
A33 Antigen (A33)
- Target
- A33
- Molecular classification
- Immunoglobulin Superfamily (IgSF), Transmembrane Glycoprotein
01
Overview
The A33 antigen is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is primarily expressed in the epithelium of the small intestine and colon, and is overexpressed in the majority of human colon cancers, making it a target for cancer immunotherapy. In viral contexts, A33 controls the incorporation of A36 into the EEV (extracellular enveloped virus) particle and is crucial for effective cell-to-cell spread.
02
Mechanism of action
Antibody-mediated targeting of A33-expressing cells, leading to cell death or inhibition of proliferation. Neutralization of viral entry/spread.
03
Biological functions
Cell adhesionCell-cell recognitionCell signalingViral entry/spread
04
Disease associations
CancerInfection
05
Safety considerations
Potential off-target effects due to A33 expression in normal colonic and small bowel epithelium.Immunogenicity of antibody-based therapies.
06
Interacting drugs
Radiolabeled antibodies against A33
2 more in the full profile.
07
Biomarkers
A33 antigen expression level in colon cancer tissue
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