AADACL2 antisense RNA 1 (AADACL2-AS1)

AADACL2 antisense RNA 1 (AADACL2-AS1) is a human long non-coding RNA gene located on chromosome 3q25.1, overlapping and transcribed antisense to the AADACL2 protein-coding gene. This lncRNA is annotated across major gene databases (HGNC, Ensembl, NCBI, LNCipedia) with several transcript variants, most of which show no protein-coding potential[3][5][6][7][9]. Its biological functions and mechanistic impact are currently unknown; however, antisense lncRNAs are often hypothesized to regulate their corresponding sense gene (AADACL2) through transcriptional or post-transcriptional mechanisms. There is weak, indirect association with breast cancer, but no established role as a drug target, biomarker, or receptor, and no clinical safety or drug interaction data[7].

Other names

AADACL2 antisense RNA 1RP11-454C18.2 (transcript alias)NONHSAT092734 (transcript alias)OTTHUMG00000159877.2 (alternative gene name)ENSG00000242908 (Ensembl gene identifier)