Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
AAV receptor (AAVR, also known as KIAA0319L) (AAVR)
- Target
- AAVR
- Molecular classification
- Glycoprotein, Receptor, Cell surface protein, Immunoglobulin-like domain protein
01
Overview
AAV receptor (AAVR/KIAA0319L), a cell surface glycoprotein with polycystic kidney disease (PKD) domains, is recognized as the canonical entry receptor for multiple AAV serotypes including AAV8. AAV8 also binds cell surface glycans as attachment factors; in some contexts, the 37/67-kDa laminin receptor (LamR) is strictly necessary for effective AAV8 cellular transduction, in contrast to AAV2, which can use alternative pathways[1][5][6]. The capsid structure of AAV8 determines specificity and efficiency of receptor engagement, shaping tissue tropism and gene delivery outcomes for gene therapies employing AAV8 vectors.
- Other names
- KIAA0319LAAVRadeno-associated virus receptorlaminin receptor (LamR, sometimes necessary for transduction[1])
02
Mechanism of action
Facilitates AAV8 virion binding, cell entry, and subsequent transduction/gene transfer
03
Biological functions
Cellular entry/virus internalizationFacilitates transduction (gene delivery via AAV8)
04
Disease associations
InfectionGene therapy
05
Safety considerations
Immunogenicity against the AAV capsid or vector proteinsOff-target transduction affecting non-target tissuesPre-existing antibodies reducing efficacy
Beyond the preview
Go deeper on AAV receptor (AAVR, also known as KIAA0319L) (AAVR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on AAV receptor (AAVR, also known as KIAA0319L) (AAVR).