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Target intelligence / Profile preview
ABCA9 antisense RNA 1 (ABCA9-AS1)
- Target
- ABCA9-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Natural antisense transcript (NAT), Non-protein coding RNA
01
Overview
ABCA9 antisense RNA 1 (ABCA9-AS1) is a long non-coding RNA transcribed from the ABCA9 locus in the reverse (antisense) direction, classified as a natural antisense transcript and located within a genomic region on chromosome 17q24.2[6]. Antisense RNAs typically regulate gene expression, often affecting the corresponding sense gene (ABCA9), and may have roles in transcriptional interference or epigenetic regulation, but the specific biological functions of ABCA9-AS1 remain uncharacterized. As a non-protein coding gene, it is not considered a therapeutic target, receptor, nor is it associated with interacting drugs or mechanisms of action, and there is no clinical biomarker evidence for this transcript[2][6].
- Other names
- ABCA9 antisense RNA 1 (non-protein coding)ABCA9-AS1
02
Biological functions
Regulation of gene expression (cis/trans effects)Potential chromatin and transcriptional modulationMay be involved in transcriptional interference or epigenetic regulation typical for antisense lncRNAs
03
Disease associations
Other (Associations reported in genome-wide studies, but no well-validated direct disease causality)
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