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Target intelligence / Profile preview
Abelson Murine Leukemia Viral Oncogene Homolog 1 (ABL1)
- Target
- ABL1
- Molecular classification
- Non-receptor tyrosine kinase, Enzyme
01
Overview
ABL1 encodes a non-receptor tyrosine kinase involved in various cellular processes including cell proliferation, differentiation, survival, and DNA repair. It is a proto-oncogene that can drive malignant transformation when mutated or aberrantly activated, most notably through the t(9;22) translocation forming the BCR-ABL fusion gene in chronic myeloid leukemia (CML). ABL1 and BCR-ABL are therapeutic targets for tyrosine kinase inhibitors.
- Other names
- Tyrosine-protein kinase ABL1Abelson murine leukemia viral oncogene homolog 1Abelson tyrosine-protein kinase 1Proto-oncogene c-Ablp150
02
Mechanism of action
Inhibition of tyrosine kinase activity of ABL1 and BCR-ABL
03
Biological functions
Cell proliferationCell differentiationCell survivalApoptosisCytoskeleton remodelingDNA repairAntigen receptor signalingSynapse formationCell cycle progressionStress response
04
Disease associations
CancerChronic Myeloid Leukemia (CML)Acute Lymphoblastic Leukemia (ALL)
05
Safety considerations
Resistance to tyrosine kinase inhibitors (TKIs)Off-target effects of TKIs
06
Interacting drugs
Imatinib mesylate (Gleevec)
07
Biomarkers
BCR-ABL fusion gene presence/absenceABL1 mutation statusBCR-ABL transcript levels
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